Tacrolimus was discovered in 1984 by a Japanese team led by T. Goto, T. Kino and H. Hatanaka, was within the first macrolide immunosuppressant discovered, preceded by the discovery of sirolimus (rapamycin) in Rapa Nui (Easter Island) in 1975. Like cyclosporin, it was found in terrestrial fungi, however, unlike This is produced by a type of bacteria, Streptomyces tsukubaensis. The name is derived from Tacrolimus 'Tsukuba macrolide immunosuppressant'. The drug is right for Astellas Pharma Inc. and sold under the trade name Prograf , Advagraf and Protopic. This is sometimes referred to as FK-506. Josyann Abisaab It was initially approved by the Food and Drug Administration (FDA) in 1994 for use in liver, and has expanded to include kidney, heart, small intestine, pancreas, lung, trachea, skin, cornea, bone marrow, and members .